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. 2015 Jul 23;5:12363. doi: 10.1038/srep12363

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Copyright © 2015, Macmillan Publishers Limited

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(A)Wound-healing assay was performed after reintroduction of Rap2B in Ctrl, Rap2B, Rap2B + BAPTA/AM and Rap2B + U0126 group in Bcap-37 and MDA-MB-231 cell lines. Starved cells were incubated with 30 μmol/L BAPTA/AM and 10 μmol/L U0126. (B) Cell migration assay was carried out after overexpression of Rap2B in Ctrl, Rap2B, Rap2B+BAPTA/AM and Rap2B+U0126 group in breast cancer cells. Starved cells were incubated with 30 μmol/L BAPTA/AM and 10 μmol/L U0126. (C) A matrigel cell invasion assay was carried out after overexpression of Rap2B in Ctrl, Rap2B, Rap2B + BAPTA/AM and Rap2B + U0126 group in breast cancer cells. Starved cells were incubated with 30 μmol/L BAPTA/AM and 10 μmol/L U0126. All experiments were carried out in triplicate. Data are presented as mean ± SD (n = 3). **P < 0.01 in comparison with respective group, and ^&P < 0.05, ^&&P < 0.05 in comparison with respective inhibitor-untreated group.