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The effect canine BRCA2 promoter region variation on promoter activity. Canine BRCA2 promoter regions, containing each variation, were cloned into the pGal4 vector. Promoter activity was analyzed by luciferase assay without or with DNA damage by 15 Gy irradiation (a and b). The promoter activity in all allele types was similar. There were no significant differences among the allele types (one-way ANOVA). Results shown represent mean ± SD of triplicate experiments
