Table 1.
Input parameters
| Parameter | Age group (Years) | |||||
|---|---|---|---|---|---|---|
| 0 - < 2 | 2 - 4 | 5 - 17 | 18 - 49 | 50 - 64 | 65+ | |
| Annual Incidence Rates per 100,000 | ||||||
| Pneumococcal meningitis | 2.5 | 0.6 | 14.6 | 5.2 | 3.4 | 6.9 |
| Pneumococcal bacteremia | 4.8 | 4.7 | 48.8 | 16.7 | 9.2 | 36.0 |
| All-cause inpatient pneumonia | 4239 | 3830 | 664 | 164 | 443 | 3700 |
| All-cause otitis media (per person) | 0.22 | 0.23 | ||||
| Percent of Meningitis that results in deafness | 13 % | 13 % | 6 % | 13 % | 13 % | 13 % |
| Percent of Meningitis that results in disability | 7 % | 7 % | 5 % | 7 % | 7 % | 7 % |
| Case-fatality rates | ||||||
| Pneumococcal meningitis | .083 | .083 | .088 | .472 | .636 | .768 |
| Pneumococcal bacteremia | .115 | .036 | .024 | .130 | .177 | .288 |
| All-cause inpatient pneumonia | .048 | .004 | .008 | .045 | .057 | .100 |
| Direct Efficacy of Vaccine | ||||||
| Pneumococcal meningitis | 73.5 % | 67.1 % | ||||
| Pneumococcal bacteremia | 73.5 % | 67.1 % | ||||
| All-cause inpatient pneumonia | 16.9 % | 22.9 % | ||||
| All-cause otitis media | 6.4 % | 5.8 % | ||||
| Indirect (herd) Effect of Vaccine | ||||||
| Pneumococcal meningitis | 46.8 % | 40.3 % | 17.5 % | 38.3 % | 17.4 % | 33.6 % |
| Pneumococcal bacteremia | 46.8 % | 40.3 % | 17.5 % | 38.3 % | 17.4 % | 33.6 % |
| All-cause inpatient pneumonia | 30.0 % | 9.0 % | 9.0 % | 12.0 % | 9.0 % | 8.0 % |
| All-cause otitis media | 20.1 % | 19.0 % | ||||
| Cost (¥) per Case of Pneumococcal Disease | ||||||
| Pneumococcal meningitis | 24347 | 14805 | 24660 | 21825 | 21331 | 34495 |
| Pneumococcal bacteremia | 24347 | 14805 | 24660 | 21825 | 21331 | 34495 |
| All-cause inpatient pneumonia | 4416 | 2466 | 2867 | 8237 | 10517 | 14493 |
| All-cause otitis media | 148 | 136 | ||||
All values measured in 2011 Chinese Yuan