Table 2.
Changes in metabolic variables and fitness by treatment arm in Look AHEAD participants with adiponectin data
| Overall sample with adiponectin data (n = 1,397) | ||||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Men and women |
Men |
Women |
||||||||
| Variable* | ILI (n = 732) | DSE (n = 665) | P value†† | ILI (n = 315) | DSE (n = 284) | P value†† | ILI (n = 417) | DSE (n = 381) | P value†† | |
| ∆ in LDL-cholesterol (mg/dL) | −3.8 (26.3) | −4.2 (28.6) | 0.76 | −4.9 (26.3) | −3.8 (27.6) | 0.61 | −2.9 (26.3) | −4.5 (29.3) | 0.4 | |
| ∆ in TG (mg/dL)† | −20 (−69, 15) | −5 (−43, 27) | <0.0001 | −32 (−84, 6) | −5 (−46, 28) | <0.0001 | −14 (−55, 23) | −5 (−41, 27) | 0.03 | |
| ∆ in HDL-cholesterol(mg/dL) | 3.5 (6.9) | 1.3 (6.6) | <0.0001 | 4.0 (6.3) | 1.7 (5.8) | <0.0001 | 3.1 (7.4) | 1.0 (7.0) | <0.0001 | |
| ∆ in HbA1c (%) | −0.7 (1.0) | −0.2 (0.9) | <0.0001 | −0.8 (1.1) | −0.3 (0.8) | <0.0001 | −0.6 (0.9) | −0.2 (0.9) | <0.0001 | |
| ∆ in HbA1c (mmol/mol) | −7.7 (10.9) | −2.2 (9.8) | −8.7 (12.0) | −3.3 (8.7) | −6.6 (9.8) | −2.2 (9.8) | ||||
| Δ in weight (kg) | −8.7 (7.6) | −0.7 (5.1) | <0.0001 | −10.2 (8.0) | −0.6 (4.5) | <0.0001 | −7.6 (7.0) | −0.7 (5.5) | <0.0001 | |
| Δ in waist (cm) | −7.4 (9.4) | −0.9 (8.2) | <0.0001 | −8.8 (9.7) | −1.1 (9.4) | <0.0001 | −6.4 (9.0) | −0.8 (7.2) | <0.0001 | |
| Δ in fitness (MET), submaximal | 1.0 (1.4) | 0.2 (1.1) | <0.0001 | 1.2 (1.5) | 0.2 (1.2) | <0.0001 | 0.9 (1.3) | 0.2 (1.0) | <0.0001 | |
| Δ in adiponectin (µg/mL)† | 0.5 (−0.4, 1.7) | 0.0 (−0.8, 0.9) | <0.0001 | 0.9 (−0.1, 1.8) | 0.1 (−0.6, 0.9) | <0.0001 | 0.3 (−0.6, 1.6) | −0.1 (−1.0, 0.9) | <0.0001 | |
| % ∆ | 11.9 (−7.2, 37.5) | 0.2 (−15.6, 20.1) | 23.6 (−2.2, 45.5) | 2.8 (−14.6, 21.8) | 6.2 (−9.6, 28.6) | −1.5 (−17.8, 18.5) | ||||
| Δ HMW-adiponectin (µg/mL)† | 0.3 (−0.1, 1.1) | 0.0 (−0.4, 0.5) | <0.0001 | 0.44 (−0.03, 1.16) | 0.05 (−0.35, 0.48) | <0.0001 | 0.27 (−0.21, 0.91) | −0.03 (−0.44, 0.46) | <0.0001 | |
| % ∆ | 21.1 (−6.4, 60.9) | 0.9 (−20.1, 28.0) | 35.9 (−1.3, 76.6) | 3.3 (−18.9, 31.9) | 14.8 (−10.6, 43.8) | −1.5 (−20.4, 23.2) | ||||
| Subset with adiponectin and body composition data (n = 490) | ||||||||||
| Men and women |
Men |
Women |
||||||||
| ILI (n = 245) | DSE (n = 245) | P value†† | ILI (n = 80) | DSE (n = 90) | P value†† | ILI (n = 165) | DSE (n = 155) | P value†† | ||
| ∆ in body composition | ||||||||||
| ∆ in total body fat (kg) | −5.97 (4.45) | 0.01 (3.63) | <0.0001 | −6.47 (4.87) | 0.01 (2.83) | <0.0001 | −5.72 (4.23) | 0.02 (4.03) | <0.0001 | |
| ∆ in total lean mass (kg) | −2.78 (2.25) | −0.22 (1.82) | <0.0001 | −3.25 (2.50) | −0.21 (1.64) | <0.0001 | −2.55 (2.08) | −0.22 (1.93) | <0.0001 | |
Data shown as mean (SD), unless otherwise noted.
TG, triglycerides.
†Median (interquartile range).
*1-year change (Δ) from baseline expressed as follow-up minus baseline values.
††For difference between ILI and DSE.