. 2015 May 13;38(8):1544–1550. doi: 10.2337/dc14-2775

Table 4.

Associations of changes in body fat and fitness with adiponectin and HMW-adiponectin by sex in a subset of participants with adiponectin and body composition data

	Men (n = 173)								Women (n = 325)
	∆ in log total adiponectin^*				∆ in log HMW-adiponectin^**				∆ in log total adiponectin^*				∆ in log HMW-adiponectin^**
Model	β	SE	P	R²	β	SE	P	R²	β	SE	P	R²	β	SE	P	R²
Models 1				0.28				0.27				0.12				0.10
∆ in weight	−0.0145	0.0047	0.002		−0.2163	0.0074	0.004		−0.0041	0.0041	0.32		−0.0047	0.0055	0.40
Models 2				0.28				0.27				0.13				0.10
∆ in total body fat	−0.0212	0.0068	0.002		−0.0312	0.0108	0.005		−0.0083	0.0050	0.10		−0.0094	0.0068	0.17
Models 3				0.25				0.25				0.11				0.09
∆ in lean body mass	−0.0272	0.0130	0.04		−0.0498	0.0205	0.02		−0.0030	0.0113	0.79		0.0025	0.0153	0.87
Models 4				0.26				0.23				0.14				0.13
∆ in fitness	0.0461	00204	0.03		0.0476	0.0325	0.15		0.0485	0.0195	0.01		0.0672	0.0263	0.01
Models 5				0.29				0.27				0.15				0.14
∆ in total body fat	−0.0183	0.0088	0.04		−0.0230	0.0142	0.11		−0.0066	0.0055	0.23		−0.0082	0.0074	0.28
∆ in lean body mass	0.0009	0.0167	0.96		−0.0184	0.0268	0.49		0.0076	0.0120	0.53		0.0164	0.0163	0.32
∆ in fitness	0.0383	0.0214	0.08		0.0031	0.0337	0.33		0.0511	0.0204	0.01		0.0697	0.0277	0.01
Models 6^†				0.33				0.33				0.27				0.27
∆ in total body fat	−0.045	0.0092	0.12		−0.0166	0.0145	0.26		−0.0050	0.0051	0.33		−0.0053	0.0069	0.44
∆ in lean body mass	0.0064	0.0170	0.71		−0.0068	0.0268	0.80		0.0154	0.0115	0.18		0.0236	0.0154	0.13
∆ in fitness	0.0383	0.0214	0.08		0.0031	0.0337	0.33		0.0421	0.0193	0.03		0.0611	0.0259	0.02

Each model was analyzed independently and adjusted for baseline adiponectin or baseline HMW-adiponectin, treatment group (ILI vs. DSE), age, race/ethnicity, clinic site, history of CVD (self-reported history of myocardial infarction, stroke, transient ischemic attack, angioplasty/stent, coronary artery bypass graft, carotid endarterectomy, abdominal aortic aneurysm, or heart failure), diabetes duration, current smoking, use of insulin, thiazolidinediones, and statins, and hormone replacement in women.

*Adjusted for baseline adiponectin.

**Adjusted for baseline HMW-adiponectin.

†Models 6 were also adjusted for changes in HbA_1c, HDL-cholesterol, and triglycerides. Prior to determination of change, adiponectin and HMW-adiponectin levels were log-transformed due to their skewed distribution.