Table 1.
Baseline Characteristics of the Study Participants
| Overall N = 1045 | FTC/TDF + EFV N = 526 | 3TC/ZDV + EFV N = 519 | |
|---|---|---|---|
| Gendera | |||
| Male | 562 (54) | 284 (54) | 278 (54) |
| Female | 483 (46) | 242 (46) | 241 (46) |
| Age (years)b | 34 (29–41) | 34 (29–41) | 34 (29–40) |
| Countrya | |||
| Brazil | 155 (15) | 76 (14) | 79 (15) |
| Haiti | 68 (7) | 33 (6) | 35 (7) |
| India | 169 (16) | 88 (17) | 81 (16) |
| Malawi | 147 (14) | 73 (14) | 74 (14) |
| Peru | 86 (8) | 44 (8) | 42 (8) |
| South Africa | 140 (13) | 70 (13) | 70 (13) |
| Thailand | 67 (6) | 35 (7) | 32 (6) |
| United States | 140 (13) | 70 (13) | 70 (13) |
| Zimbabwe | 73 (7) | 37 (7) | 36 (7) |
| CD4+ count (cells/µL)b | 167 (89–228) | 162 (86–221) | 169 (92–237) |
| HIV-1 RNA (log10 copies/mL)b | 5.0 (4.6–5.4) | 5.0 (4.5–5.5) | 5.0 (4.6–5.4) |
| AIDS diagnosis (current or prior)a | 113 (11) | 55 (10) | 58 (11) |
| Weight (kg)c | 62.9 (14.0) | 62.3 (13.8) | 63.4 (14.2) |
| BMI (kg/m2)c,d | 23.2 (4.4) | 23.0 (4.4) | 23.4 (4.5) |
| Underweighta | 91 (9) | 54 (10) | 37 (7) |
| Normala | 680 (65) | 340 (65) | 340 (66) |
| Overweight or obesea | 274 (26) | 132 (25) | 142 (27) |
| Mid-arm Circumference (cm)c | 28.0 (4.0) | 27.8 (4.0) | 28.2 (4.0) |
| Mid-thigh Circumference (cm)c | 47.9 (6.6) | 47.5 (6.3) | 48.3 (6.8) |
| Waist Circumference (cm)c | 79.5 (10.2) | 79.1 (10.3) | 79.9 (10.1) |
| High-risk circumferencea,e | 222 (22) | 107 (21) | 115 (23) |
| Hip circumference (cm)c | 92.5 (10.2) | 92.0 (10.0) | 93.0 (10.3) |
| Waist-to-Hip Ratioc | 0.86 (0.08) | 0.86 (0.07) | 0.86 (0.08) |
| High-risk ratioa,f | 387 (38) | 195 (38) | 192 (38) |
Abbreviations: AIDS, acquired immune deficiency syndrome; BMI, body mass index; EFV, efavirenz; FTC, emtricitabine; TDF, tenofovir; ZDV, zidovudine; 3TC, lamivudine.
a N (%).
b Median (25th and 75th percentile).
c Mean (standard deviation).
d BMI categories: underweight (<18.5 kg/m2), normal (18.5–24.9 kg/m2), overweight or obese (≥25.0 kg/m2).
e High-risk waist circumference defined as >94 cm for male or >80 cm for female.
f High-risk waist-to-hip ratio defined as ≥0.90 for male or ≥0.85 for female.