Table 3.

Associations between SENP1 immunohistochemistry results and cell proliferation as measured by Ki67 immunohistochemistry in all cancers and subsets of cancers defined by Gleason grade, and the ERG/PTEN status. Ki67LIav = average Ki67 labeling index. * P-value for SENP1 negative vs. positive (combined groups of weak, moderate, strong)

		SENP1 IHC	Number	Ki67LI av		P
All cancers		negative	3,880	2.58	±0.04
		weak	679	3.05	±0.10	<0.0001
		moderate	838	3.31	±0.09	* < 0.0001
		strong	419	3.21	±0.13
Gleason	≤3 + 3	negative	980	2.07	±0.07
		weak	112	2.30	±0.19	<0.0001
		moderate	137	2.55	±0.18	* < 0.0001
		strong	75	2.65	±0.24
	3 + 4	negative	2,238	2.51	±0.05
		weak	396	3.02	±0.12	<0.0001
		moderate	520	3.14	±0.10	* < 0.0001
		strong	252	3.24	±0.15
	4 + 3	negative	504	3.34	±0.16
		weak	119	3.69	±0.32	0.4329
		moderate	137	3.85	±0.30	*0.1209
		strong	71	3.56	±0.42
	≥4 + 4	negative	133	4.74	±0.39
		weak	51	3.41	±0.63	0.0516
		moderate	41	5.90	±0.70	*0.5643
		strong	18	3.78	±1.06
ERG-positive cancers without PTEN deletion		negative	814	2.92	±0.09
		weak	151	3.44	±0.21	0.0315
		moderate	196	2.99	±0.19	*0.0293
		strong	80	3.59	±0.29