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. 2015 Apr 9;64(8):2817–2827. doi: 10.2337/db14-1943

Figure 2.

Figure 2

DGAT1 overexpression does not adversely affect cardiac function or energetics. A: RPP (the product of LVDevP and heart rate) measured in Langendorff isolated perfused hearts (n = 28–32). B: Percent oxidation of fatty acids (FA), glucose (GLC), and unlabeled substrates (UNL) (lactate, glycogen, and TAG) in extracts from isolated perfused hearts analyzed by 13C NMR spectroscopy (n = 7 each group). C: PCr-to-ATP ratio (PCr/ATP) measured by 31P NMR spectroscopy in isolated perfused hearts (n = 8–9). D: Heart weight normalized to tibia length (HW:TL) in CON and MHC-DGAT1 (DGAT) mice at 3 months (n = 11–12), 6 months (n = 5–7), 9 months (n = 4 each), and 12 months (n = 8 each) of age. E–H: Fractional shortening (FS), LV posterior wall thickness at diastole (LVPW:d), LV internal dimension at diastole (LVID:d), and heart rate (HR) in 12-month-old CON and DGAT mice assessed by echocardiography (n = 3–4).