Table 3.
Characteristic of the study sample by tertiles of plasma fibrinogen recovery to mental stress task (proportional decrease from immediate post task to 45 min post task), for 491 disease-free participants drawn from the Whitehall II epidemiological cohort between 2006 and 2008 in United Kingdom.
| Factor and category | Tertiles of plasma fibrinogen recovery (proportional decrease) |
P value | |||||
|---|---|---|---|---|---|---|---|
| Lowest | Medium | Highest | |||||
| Age (mean years ± s.d.) | 63.9 | ±6.1 | 62.8 | ±5.7 | 62.3 | ±5.1 | 0.115 |
| Male (%) | 51.5 | 55.6 | 56.4 | 0.881 | |||
| Latest grade of employment (%) | |||||||
| Higher | 41.5 | 39.2 | 35.5 | 0.428 | |||
| Intermediate | 39.2 | 33.9 | 43.0 | ||||
| Lower | 19.3 | 26.9 | 21.5 | ||||
| Current smoker (%) | 6.4 | 7.0 | 3.5 | 0.085 | |||
| Alcohol consumption (%) | |||||||
| No alcohol | 15.2 | 17.0 | 15.7 | 0.875 | |||
| Below recommended levels | 70.2 | 72.5 | 70.3 | ||||
| Above recommended levels | 14.6 | 10.5 | 14.0 | ||||
| Hours of physical activity per week (%) | |||||||
| <1 h | 25.4 | 23.8 | 21.2 | 0.423 | |||
| 1–4 h | 32.5 | 33.9 | 29.1 | ||||
| 5–7 h | 20.1 | 22.0 | 26.7 | ||||
| >7 h | 21.9 | 20.2 | 23.0 | ||||
| Body mass index (mean kg/m2 ± s.d.) | 26.0 | ±4.1 | 25.9 | ±3.9 | 25.5 | ±3.8 | 0.357 |
| Systolic blood pressure (mean mmHg ± s.d.) | 128.6 | ±15.2 | 128.8 | ±16.2 | 129.9 | ±16.5 | 0.934 |
| Diastolic blood pressure (mean mmHg ± s.d.) | 69.4 | ±7.9 | 69.5 | ±8.2 | 70.3 | ±9.9 | 0.917 |
| Glycated haemoglobin (mean % ± s.d.) | 5.5 | ±0.6 | 5.5 | ±0.4 | 5.4 | ±0.4 | 0.895 |
| Triglycerides (median g/L ± IQR) | 1.3 | ±0.7 | 1.2 | ±0.8 | 1.0 | ±0.9 | 0.100 |
| HDL (mean mmol/L ± s.d.) | 1.7 | ±0.5 | 1.7 | ±0.5 | 1.6 | ±0.4 | 0.325 |
| LDL (mean mmol/L ± s.d.) | 3.1 | ±1.0 | 2.9 | ±0.7 | 3.0 | ±0.8 | 0.705 |
| Total cholesterol (mean mmol/L ± s.d.) | 5.4 | ±1.0 | 5.2 | ±0.8 | 5.3 | ±0.9 | 0.142 |
| Total cholesterol/HDL ratio (mean ± s.d) | 3.5 | ±1.2 | 3.4 | ±1.1 | 3.4 | ±1.0 | 0.825 |
| C-reactive protein (median mg/L ± IQR) | 1.1 | ±1.3 | 1.1 | ±1.6 | 0.9 | ±1.1 | 0.178 |
| Salivary cortisol (mean nmol/L ± s.d.) | 6.7 | ±4.4 | 6.5 | ±4.4 | 6.1 | ±3.5 | 0.586 |
| IL-6 (median pg/ml ± IQR) | 1.2 | ±0.8 | 1.2 | ±0.9 | 1.0 | ±0.7 | 0.206 |
| Von Willebrand factor (mean % ± s.d.) | 105.8 | ±38.0 | 105.9 | ±38.1 | 101.0 | ±42.3 | 0.230 |
| MCP-1 (median pg/mL ± IQR) | 145.3 | ±55.2 | 133.5 | ±51.8 | 135.9 | ±63.2 | 0.015 |
| Fibrinogen (mean mg/dL ± s.d.) | 316.5 | ±60.7 | 323.3 | ±63.7 | 304.6 | ±59.6 | 0.363 |
| Salivary cortisol response (mean % increase ± s.d.) | 8.5 | ±41.7 | 17.3 | ±66.8 | 22.9 | ±67.3 | 0.135 |
| IL-6 response (mean % increase ± s.d.) | 3.2 | ±16.1 | 2.4 | ±14.1 | 0.9 | ±12.4 | 0.011 |
| Von Willebrand factor response (mean % increase ± s.d.) | 3.3 | ±21.7 | 5.7 | ±24.6 | 7.1 | ±19.8 | 0.005 |
| MCP-1 response (mean % increase ± s.d.) | 12.6 | ±29.4 | 6.0 | ±18.3 | 4.3 | ±17.8 | <0.001 |
| Fibrinogen response (mean % increase ± s.d.) | 1.6 | ±7.5 | 5.5 | ±5.4 | 8.4 | ±7.2 | <0.001 |
| Fibrinogen recovery (mean % decrease ± s.d.) | −5.0 | ±8.7 | 2.9 | ±1.4 | 8.8 | ±3.3 | |
| Agatston coronary calcium score (%) | |||||||
| None | 43.9 | 45.0 | 42.4 | 0.999 | |||
| <100 | 31.0 | 33.9 | 31.4 | ||||
| <400 | 16.4 | 11.1 | 16.9 | ||||
| 400+ | 8.8 | 9.9 | 9.3 | ||||
| HS-CTnT detectable (>3 ng/L) (%) | 20.6 | 17.6 | 12.9 | 0.365 | |||
| HS-CTnT concentration if detectable (geom. mean ng/L ± s.d.) | 5.5 | ±1.6 | 6.7 | ±1.8 | 7.4 | ±2.0 | 0.105 |
P values were computed using the likelihood ratio test. All variables were measured at baseline with the exception of response variables (calculated as the proportional increase from baseline to immediately post task) and fibrinogen recovery (calculated as the proportional decrease from immediate post task to 45 min post task). HS-CTnT was measured at 75 min post task. Tertiles of plasma fibrinogen recovery (%): lowest = from −68.5 to 0.3; medium = from 0.4 to 5.2; highest = from 5.2 to 23.1.