Table 4.

Multiple logistic regression models for the association between baseline fibrinogen, fibrinogen response to mental stress tasks, or fibrinogen recovery and plasma detectable HS-CTnT, for 491 disease-free participants drawn from the Whitehall II epidemiological cohort between 2006 and 2008 in England.

Model for detectable HS-cTnT (outcome variable)	Exposure variable
	Baseline fibrinogen (OR for 1 g/L)			Fibrinogen response (OR for 10% increase)			Fibrinogen recovery (OR for 10% decrease)
	OR	(95% CI)	P	OR	(95% CI)	P	OR	(95% CI)	P
1. Crude association	1.41	(0.97–2.04)	0.072	0.63	(0.45–0.88)	0.007	0.99	(0.96–1.01)	0.365
2. Adjusted for age, gender, and baseline fibrinogen when exposure is fibrinogen response or recovery	1.35	(0.89–2.05)	0.154	0.61	(0.41–0.90)	0.014	0.99	(0.96–1.03)	0.601
3. With further adjustment for latest grade of employment, smoking, alcohol consumption, and physical activity	1.27	(0.83–1.95)	0.265	0.61	(0.41–0.91)	0.015	0.99	(0.96–1.03)	0.683
4. With further adjustment for systolic and diastolic blood pressure, LDL, total cholesterol/HDL ratio, triglycerides, glycated haemoglobin, and BMI	1.13	(0.71–1.79)	0.607	0.57	(0.37–0.88)	0.011	0.99	(0.95–1.02)	0.480
5. With further adjustment for baseline values of CRP, salivary cortisol, IL6, vWF, and MCP-1	1.05	(0.58–1.91)	0.878	0.53	(0.34–0.83)	0.006	0.98	(0.94–1.02)	0.250
6. With further adjustment for response values of salivary cortisol, IL6, vWF, and MCP-1	0.97	(0.50–1.85)	0.919	0.49	(0.30–0.81)	0.006	0.98	(0.94–1.02)	0.284
7. With further adjustment for coronary calcification (Agatston score in 4 categories)	0.92	(0.48–1.76)	0.798	0.49	(0.30–0.82)	0.007	0.98	(0.94–1.02)	0.246

All variables were measured at baseline with the exception of response variables (calculated as the proportional increase from baseline to immediately post task) and fibrinogen recovery (calculated as the proportional decrease from immediate post task to 45 min post task). HS-CTnT was measured at 75 min post task.