Table 1. Summary of rates of tract length change calculated from liquid, colony, and microcolony time courses.
Genotype | Rates of tract length changes | ||
---|---|---|---|
Liquida (95% C.I.)b | Colony (95% C.I.) | Microcolony (95% C.I) | |
MSH3(CTG) | 1.2 × 10−3 (9.0 × 10−4 to 1.6 × 10−3) | 1.5 × 10−2 (1.2 × 10−2 to 1.9 × 10−2) | 3.5 × 10−2 (2.8 × 10−2 to 4.2 × 10−2)e |
MSH3(CAG) | 3.1 × 10−3 (2.4 × 10−3 to 3.4 × 10−3) | NDc | ND |
msh3Δ(CTG) | 3.1 × 10−4 (1.3 × 10−4 to 6.0 × 10−4) | 3.6 × 10−3 (1.5 × 10−3 to 7.2 × 10−3)d | 1.6 × 10−2 (1.1 × 10−2 to 2.2 × 10−2)f |
msh3Δ(CAG) | 1.3 × 10−4 (2.9 × 10−4 to 3.7 × 10−4) | ND | ND |
MSH3(CTG)25 | <5 × 10−5g,h | ND | <1.2 × 10−3g,h |
MSH3(CAG)25 | 5.1 × 10−5h | ND | ND |
Expansions only.
95% C.I.s determined by F-statistic.
Not determined.
Predominantly contractions.
Slight bias toward expansions.
Bias toward contractions.
No tract changes observed.
Low numbers precluded accurate calculation of 95% C.I.