Table 2.
Effects of E. longifolia extract on CYP-specific metabolite formation in human liver microsomes.
| P450 isozyme (Specific metabolite) |
Metabolite formation (% of control) | ||||||
|---|---|---|---|---|---|---|---|
| E. longifolia extract (µg/mL) | |||||||
| 1 | 3 | 10 | 30 | 100 | 300 | 1000 | |
| CYP1A2 (Acetaminophen) |
92.0 | 95.5 | 91.0 | 89.1 | 71.3 | 68.4 | 26.9 |
| CYP2A6 (7-OH-coumarin) |
96.1 | 104.1 | 79.8 | 86.8 | 79.1 | 76.6 | 56.4 |
| CYP2C8 (6-OH-paclitaxel) |
88.1 | 95.6 | 85.5 | 100.1 | 86.1 | 86.7 | 103.3 |
| CYP2C9 (4-OH-diclofenac) |
92.2 | 104.0 | 93.6 | 97.2 | 92.3 | 84.9 | 88.0 |
| CYP2C19 (4-OH-mephenytoin) |
91.3 | 106.6 | 85.7 | 90.1 | 77.8 | 50.2 | 45.9 |
| CYP2D6 (Dextrorphan) |
91.1 | 88.8 | 81.4 | 93.3 | 82.6 | 80.0 | 77.4 |
| CYP3A4 (1-OH-midazolam) |
96.7 | 106.4 | 88.3 | 93.6 | 90.0 | 97.7 | 101.4 |