Figure 10.

The hCAPN5^R243L transgenic retina shows early changes in inflammatory gene expression before any clinical or histological signs of disease. (A) Volcano plot displays genes in the hCAPN5^R243L retinas at post-natal day (P) 45 that had statistically significant expression changes that were greater than 2-fold (P < 0.05), when compared with P45 control retinas. Four genes (Fos, Bcl6, IL1rap and Nr3c1) were downregulated (blue dots, upper left). (B) Schematic representation shows that several members of the TLR pathways were among the upregulated inflammatory genes.