Figure 7.
The hCAPN5R243L transgenic mouse develops severe uveitis that phenocopies early-stage human ADNIV. (A) Pupil-optic nerve section of a normal mouse eye. (B) Pupil-optic nerve section of a hCAPN5R243L transgenic mouse eye at 4 months of age. The anterior segment shows signs of inflammation with protein exudates in the anterior chamber and a contracted iris with dilated vessels. There are membranes and cells in the vitreous chamber. (C) Magnified view of foreshortened iris and dilated vessels (arrow). (D) Posterior epithelial cells (green arrow) are a sign of posterior subcasular cataract. Vitreous vessels (green arrow) are a sign of early vitreous neovascularization. (E) Vitreous membranes (arrow) correlate with fibrotic bands found in the human vitreous. (F) Control retina. (G) Retinal vessels are dilated (arrow). (H) Reactive retinal pigmented epithelial cells (arrow) in early retinal degeneration. (I) Fibrovascular tissue at optic nerve (arrow).