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. 2015 Jun 1;24(16):4764–4773. doi: 10.1093/hmg/ddv196

Table 2.

Frequency of de novo variants by top 25% mouse RNA expression

Category Total number of de novo variants
Frequency of de novo variants/subject
Fold enrichment (95% CI)a P-value*
CDH trios (n = 39) Control (n = 787) CDH trios (n = 39) Controls (n = 787)
Synonymous 0 45 0 0.06 0 (0–21.18) 1.000
LGD 5 19 0.13 0.02 4.41 (1.82–21.18) 0.005
Likely deleterious 8 45 0.21 0.06 3.20 (1.64–21.18) 0.003
All protein changing 13 151 0.33 0.19 1.68 (1.01–21.18) 0.048
All variants 13 196 0.33 0.25 1.32 (0.79–21.18) 0.191

Bold fonts indicate significant after Bonferroni correction.

aThe fold enrichment is the ratio of variants in cases to variants in controls divided by the ratio of cases to controls.

*P-values compare the number of variants in each category between cases and controls using a two-sided binomial exact test (uncorrected).

CI, confidence interval.