. 2015 Jun 1;24(16):4764–4773. doi: 10.1093/hmg/ddv196

Table 3.

Frequency of de novo variants in CDH cases and controls by top 25% mouse RNA expression compared with expected mutation rate

Class	Cases (n = 39)			P-value*	Controls (n = 787)		Fold enrichment^a	P-value*
Class	Expected	Observed	Fold enrichment^a	P-value*	Expected	Observed	Fold enrichment^a	P-value*
All	9.38	13	1.40	0.154	189.36	193	1.00	0.405
Synonymous	2.63	0	0.00	1.000	53.06	44	0.83	0.909
Missense	6.23	8	1.30	0.288	125.63	126	1.00	0.499
LGD	0.93	5	5.40	0.003	18.86	18	0.95	0.609

Bold fonts indicate significant after Bonferroni correction.

^aThe fold enrichment is the ratio of observed variants to expected variants.

*P-values compare the number of observed variants to the number of expected variants using a one-tailed Poisson exact test.