Table 3.
Class | Cases (n = 39) |
P-value* | Controls (n = 787) |
Fold enrichmenta | P-value* | |||
---|---|---|---|---|---|---|---|---|
Expected | Observed | Fold enrichmenta | Expected | Observed | ||||
All | 9.38 | 13 | 1.40 | 0.154 | 189.36 | 193 | 1.00 | 0.405 |
Synonymous | 2.63 | 0 | 0.00 | 1.000 | 53.06 | 44 | 0.83 | 0.909 |
Missense | 6.23 | 8 | 1.30 | 0.288 | 125.63 | 126 | 1.00 | 0.499 |
LGD | 0.93 | 5 | 5.40 | 0.003 | 18.86 | 18 | 0.95 | 0.609 |
Bold fonts indicate significant after Bonferroni correction.
aThe fold enrichment is the ratio of observed variants to expected variants.
*P-values compare the number of observed variants to the number of expected variants using a one-tailed Poisson exact test.