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. Author manuscript; available in PMC: 2015 Jul 23.
Published in final edited form as: Nat Chem. 2013 Mar 31;5(5):423–427. doi: 10.1038/nchem.1612

Figure 1. Use of LA-LDI-TOF-MS to monitor progress of a representative known reaction.

Figure 1

a, General strategy for monitoring the progress of chemical reactions using LA-LDI-TOF-MS, which entails labeling one of the reactants with a tag that permits matrix-free laser-induced desorption/ionization and rapid detection of any products originating from such labeled analyte. b, Reaction scheme of a representative chemical transformation of 1 to 2, which was studied using LA-LDI-TOF-MS. c, MS spectra for conversion of alcohol 1 to ester 2. d, Plot of relative ion intensity ratio (I2/I1) vs mole ratio (M2/M1) (y = 0.1324x + 0.0216, R2 = 0.99365). Error bars represent standard deviations.