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. Author manuscript; available in PMC: 2015 Jul 23.
Published in final edited form as: Nat Chem. 2013 Mar 31;5(5):423–427. doi: 10.1038/nchem.1612

Figure 2. Reaction screen using LA-LDI-TOF-MS and identification of two catalytic benzannulations.

Figure 2

Figure 2

Figure 2

a, High-throughput screening of 696 potential reactions. Siloxy alkyne 3 contains a pyrene tag, which enables matrix-free detection of any products originating from this compound using LA-LDI-TOF-MS platform. TADDOL: (α,α,α,α-tetraaryl-1,3-dioxolane-4,5-dimethanol); DMAP: 4-Dimethylaminopyridine; DABCO: 1,4-diazabicyclo[2.2.2]octane; TASF: tris(dimethylamino)sulfonium difluorotrimethylsilicate. b, Initial identification of the benzannulation of siloxy alkyne 3 with 2-pyrone in the presence of AuCl3 to give carboxylic acid 4. c, Initial identification of the benzannulation of siloxy alkyne 3 with N-isoquinoline oxide in the presence of AgNTf2 to give oxime 5.