Table 1. Transthoracic echocardiography of Myh6 MerCreMer/+ mice.
| TMX dose (mg/g/day) | Genotype | Number (n) | HR (BPM) | LVID,s (mm) | LVID,d (mm) | FS (%) | LVAW,d (mm) | LVAW,s (mm) | LVPW,d (mm) | LVPW,s (mm) | EF (%) |
|---|---|---|---|---|---|---|---|---|---|---|---|
| Baseline | Wild type | 10 | 465 ± 48 | 2.72 ± 0.26 | 4.24 ± 0.20 | 35.8 ± 4.6 | 0.83 ± 0.03 | 1.29 ± 0.05 | 0.84 ± 0.02 | 1.28 ± 0.06 | 62.7 ± 5.0 |
| Myh6 MerCreMer/+ | 10 | 482 ± 45 | 2.68 ± 0.19 | 4.11 ± 0.13 | 34.8 ± 4.7 | 0.83 ± 0.03 | 1.29 ± 0.04 | 0.85 ± 0.02 | 1.27 ± 0.04 | 62.4 ± 4.6 | |
| p-value | 0.41 | 0.67 | 0.10 | 0.62 | 0.59 | 0.79 | 0.09 | 0.92 | 0.89 | ||
| 0.1 | Wild type | 6 | 441 ± 44 | 2.75 ± 0.23 | 4.37 ± 0.27 | 36.9 ± 2.6 | 0.86 ± 0.02 | 1.31 ± 0.02 | 0.86 ± 0.02 | 1.31 ± 0.02 | 67.0 ± 3.4 |
| Myh6 MerCreMer/+ | 6 | 421 ± 22 | 2.66 ± 0.06 | 4.14 ± 0.13 | 35.5 ± 1.6 | 0.85 ± 0.03 | 1.31 ± 0.05 | 0.84 ± 0.03 | 1.29 ± 0.04 | 65.4 ± 2.0 | |
| p-value | 0.36 | 0.37 | 0.09 | 0.29 | 0.40 | 1.00 | 0.34 | 0.27 | 0.35 | ||
Normal left ventricular dimensions and function of Myh6 MerCreMer/+ mice in comparison to wild type controls. TMX, Tamoxifen; Heart rate, HR; left ventricular internal diameter, diastole, LVID,d; LVID, systole, LVID,s; fractional shortening, FS; left ventricular anterior wall, systole, LVAW,s; LVAW, diastole, LVAW,d; left ventricular posterior wall, diastole, LVPW,d; LVPW, systole, LVPW,s; ejection fraction, EF. Groups were compared using Student’s t-test. P < 0.05 was considered significant. All values were expressed as mean ± STDEV.