Table 1. Cross kingdom enzyme stimulators for secreted bacterial toxins.
| Strain | Enzyme | Stimulated Activity | Activator |
|---|---|---|---|
| Pseudomonas aeruginosa | ExoU | PLA2/Lyso-PLA | Ubiquitin |
| Pseudomonas fluorescens | ExoU-like | PLA2 | Ubiquitin |
| Photorhabdus asymbiotica | LopU | PLA2 | Ubiquitin |
| Burkholderia thailandensis | ExoU-like | PLA2 | Ubiquitin |
| Rickettsia prowazekii | RP534 | PLA1/PLA2/Lyso-PLA2 | bSOD(ubiquitin) |
| Rickettsia typhi | RT0590/Pat1 | PLA2 | bSOD(ubiquitin) |
| Rickettsia typhi | RT0522/Pat2 | PLA2 | bSOD(ubiquitin) |
| Legionella pneumophila | VipD | PLA1 | Rab5 |
| Salmonella typhimurium | SseJ | Esterase | GTP-RhoA |
| Bordetella pertussis | CyaA | Nucleotidyl cyclase | Calmodulin |
| Bacillus anthracis | Edema factor | Nucleotidyl cyclase | Calmodulin |
| Pseudomonas aeruginosa | ExoY | Nucleotidyl cyclase | Actin? |
| Aeromonas hydrophila | AexU | ADP-ribosyltransferase | 14-3-3 |
| Aeromonas spp. | AexT | ADP-ribosyltransferase | 14-3-3 |
| Pseudomonas aeruginosa | ExoS | ADP-ribosyltransferase | 14-3-3 |
| Pseudomonas aeruginosa | ExoT | ADP-ribosyltransferase | 14-3-3 |
| Vibrio parahaemolyticus | VopT | ADP-ribosyltransferase | 14-3-3 |
| Vibrio cholerae | Cholera toxin | ADP-ribosyltransferase | ARF |
| Escherichia coli | Heat labile toxin | ADP-ribosyltransferase | ARF |
| Shigella flexneri | OspG | Kinase | E2-Ubiquitin |
| Yersinia pestis | YopO/YpkA | Kinase | G-actin |
| Pseudomonas syringae | HopZ1 | Acetyl transferase | IP6 |
| Yersinia spp. | YopJ | Acetyl transferase | IP6 |
| Salmonella typhimurium | AvrA | Acetyl transferase | IP6 |
| Vibrio parahaemolyticus | VPA1380 | Cysteine protease | IP6 |
| Pseudomonas syringae | AvrRpt2 | Cysteine protease | Cyclophilin |
| Totals | 26 | 9 | 12 |