Table 1. Included Study Characteristics.
| Study (Author, year) | Methods | Participants | Outcomes | Ethnicity | Country | Diagnostic Criteria |
|---|---|---|---|---|---|---|
| Rees 1997 a | DNA was extracted from peripheral blood and the DQB1 alleles were identified by PCR. | GBS cases = 97; Healthy Controls = 100 | DQB1*020x DQB1*030x DQB1*040x DQB1*050x DQB1*0601 | Caucasian | England/Wales | Asbury and Cornblath |
| Koga 1998 | DQB1 alleles were typed using the PCR-dependent preferential heteroduplex formation assay. | GBS cases = 35; Healthy Controls = 112 | DQB1*020x DQB1*030x DQB1*040x DQB1*050x DQB1*060x | Asian | Japan | Asbury and Cornblath |
| Ma 1998 | HLA-DQB1 allele typing was performed using a modified PCR-restriction fragment length polymorphism method combined with group-specific primers. | GBS cases = 81; Healthy Controls = 87 | DQB1*030x DQB1; 040x DQB1*050x DQB1*060x | Asian | Japan | Asbury and Cornblath |
| Li 2000 | DNA was extracted from white blood cells and the HLA typing was performed using PCR with sequence-specific primers. | GBS cases = 47; Healthy Controls = 50 | DQB1*020x DQB1*030x DQB1*040x DQB1*050x DQB1*060x | Asian | China | Asbury and Cornblath |
| Magira 2003 b | Genomic DNA was obtained and HLA typing performed by PCR with sequence-specific primers. | GBS cases = 72 (47 AMAN, 25 AIDP); Healthy Controls = 97 | DQB1*020x DQB1*030x DQB1*040x DQB1*050x DQB1*060x | Asian | China | Asbury and Cornblath |
| Geleijns 2005 | Genomic DNA was extracted from whole blood samples and the HLA type was determined at the two-digit level using PCR with sequence-specific primers. | GBS cases = 164; Healthy Controls = 207 | DQB1*02 DQB1*03 DQB1*04 DQB1*05 DQB1*06 | Caucasian | Netherlands | Asbury and Cornblath |
| McCombe 2006 | Genomic DNA was extracted from whole blood and the HLA-DQB alleles were typed using Dynal low-resolution SSP kits. | GBS cases = 74; Healthy Controls = 158 | DQB1*050x DQB1*060x | Caucasian (n = 73) and Asian (n = 1) | Australia | Asbury and Cornblath |
| Sinha 2010 c | Genomic DNA was isolated from whole blood and the HLA type at the HLA-II DQB1 locus was determined at the two-digit level using PCR with sequence-specific primers. | GBS cases = 54; Healthy Controls = 202 | DQB1*0201 DQB1*030x DQB1*040x DQB1*050x DQB1*060x | Asian | India | Asbury and Cornblath; subtype diagnosis based on Hadden et al. |
| Fekih-Mrissa 2014 | Genomic DNA was extracted from peripheral blood samples, and low-resolution HLA typing was performed using Micro SSP DNA typing trays DRB/DQB. | GBS cases = 38; Healthy Controls = 100 | DQB1*020x DQB1*030x DQB1*050x DQB1*060x | Arabic | Tunisia | Asbury and Cornblath |
a Blood samples were obtained from 103 GBS cases for a previous study, but only 93 were available for the analyses in this study. An additional four cases were recruited between the end of the first study and the analysis for this study.
b All participants were diagnosed with GBS; however, for this study they were divided into the AMAN and AIDP forms of GBS.
c HLA typing was performed on a subset of randomly selected GBS cases from a larger cohort (n = 80) and compared to a pool of 202 healthy controls rather than the pool of 80 matched healthy controls recruited for the case/control section of the study.