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. Author manuscript; available in PMC: 2015 Jul 23.
Published in final edited form as: Cell Rep. 2015 Jul 9;12(3):482–494. doi: 10.1016/j.celrep.2015.06.043

Figure 6. Re-specification of the vMGE towards the POA fate in Otx2 RxCre cKOs.

Figure 6

ISH on E11.5 coronal hemisections from (A–S) Otx2f/+, (A’–O’) Otx2f/−; RxCre, and (P’S’) Otx2f/−; Nkx2.1Cre embryos showing expanded expression of POA genes (A–M’, U–W’) and diminished expression of vMGE genes (N–S’, T–T’) in cKOs. For each experiment (except Tal2 and Slit2 in Nkx2.1Cre cKOs), two or three sections are shown to demonstrate effects at different rostral-caudal planes. (A–C’) Hmx2 (Nkx5.2), (D–F’) Dbx1, (G–G’) Tgfb3, (H–I’, U–U’) Slit2, (J–K’) Arhgap22, (L–M’, V–W’) Sox14, (N–O’, T–T’) Tal2, (P–Q’) Tll2, (R–S’) Sall3. Scale bars: 0.5mm.