Table 1.
Entry criteria and markers of congestion in DOSE and CARRESS.
| DOSE | CARRESS | |
|---|---|---|
| Number of patients | 308 | 188 |
| LVEF | HFrEF and HFpEF | HFrEF and HFpEF |
| Inclusion | Documented HF on loop diuretic > 1 month |
Onset of cardiorenal syndrome after hospitalization for ADHF, or worsening renal function in preceding 12 weeks. |
| Evidence of congestion | 1 sign (rales, peripheral edema, ascites or pulmonary vascular congestion on CXR) AND 1 symptom (dyspnea, orthopnea or edema) |
2 of the following:
|
| Moderate or severe peripheral edema |
79% | 89% |
| JVP>8cmH20 | 81% | 97% |
| ≥ 2 pillow orthopnea | 78% | 82% |
LVEF = Left ventricular ejection fraction; HFrEF = Heart failure with reduced ejection fraction HFpEF = heart failure with preserved ejection fraction; HF = heart failure; ADHF = acute decompensated heart failure; CXR = chest x-ray; JVP= jugular venous pressure