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. Author manuscript; available in PMC: 2016 Jul 1.
Published in final edited form as: Circ Heart Fail. 2015 May 18;8(4):788–798. doi: 10.1161/CIRCHEARTFAILURE.114.001963

Figure 5.

Figure 5

A. Smad3 loss attenuates oxidative and nitrosative stress in WT and db/db hearts. DCFDA assay showed that db/db hearts had increased ROS levels when compared with age-matched WT hearts (*p<0.05 vs WT). Partial or complete loss of Smad3 markedly reduced myocardial ROS levels in WT and in db/db animals (^p<0.05, ^^p<0.01 vs. WT; **p<0.01 vs. db/db, n=6/group). B-C. 3-nitrotyrosine expression was markedly increased in db/db hearts (**p<0.01 vs WT). Smad3 loss in db/db mice resulted in attenuated 3-nitrotyrosine expression (**p<0.01 vs. db/db).