Table 2.
Univariate analysis according to clinicopathological factors in advanced rectal cancer patients.
| Factor | No. of patients | Median OS, mo | p value | Median DFS, mo | p value |
|---|---|---|---|---|---|
| Sex | 0.22 | 0.08 | |||
| Male | 111 | 46.7 | 20.3 | ||
| Female | 69 | 40.2 | 20.2 | ||
| Age, yr | 0.60 | 0.35 | |||
| < 65 | 117 | 43.0 | 17.8 | ||
| ≥ 65 | 63 | 57.9 | 29.6 | ||
| Distance from anal verge, cm | 0.98 | 0.98 | |||
| < 7 | 111 | 44.7 | 21.9 | ||
| ≥ 7 | 69 | 42.2 | 19.5 | ||
| Pathological type | 0.042 | 0.024 | |||
| Canalicular adenoma | 157 | 45.5 | 23.2 | ||
| Mucinous adenoma | 23 | 34.5 | 16.4 | ||
| Differentiation | 0.007 | 0.022 | |||
| Well | 28 | 67.5 | 11.2 | ||
| Moderate | 138 | 46.7 | 23.2 | ||
| Poor | 14 | 33.4 | 17.7 | ||
| LNs examined | 0.001 | < 0.001 | |||
| < 12 | 83 | 39.4 | 15.8 | ||
| ≥12 | 97 | 59.1 | 32.2 | ||
| LNR | 0.004 | 0.002 | |||
| 0 | 51 | 64.2 | 32.9 | ||
| ≤ 0.19 | 15 | 59.1 | 30.4 | ||
| > 0.19 | 114 | 37.6 | 17.8 | ||
| pN stage | < 0.001 | < 0.001 | |||
| N0 | 46 | 68.5 | 35.4 | ||
| N1a | 10 | 52.9 | 15.8 | ||
| N1b | 36 | 59.1 | 16.4 | ||
| N1c | 12 | 26.7 | 12.7 | ||
| N2a | 35 | 46.7 | 34.0 | ||
| N2b | 41 | 27.2 | 20.2 | ||
| TNM stage | < 0.001 | 0.001 | |||
| II | 46 | 68.5 | 35.4 | ||
| IIIA | 6 | 75.7 | 24.7 | ||
| IIIB | 66 | 45.6 | 17.7 | ||
| IIIC | 62 | 29.7 | 15.8 | ||
| Postoperative chemotherapy | 0.48 | 0.22 | |||
| Yes | 168 | 45.2 | 20.2 | ||
| No | 12 | 19.7 | |||
| Postoperative radiotherapy | < 0.001 | < 0.001 | |||
| Yes | 101 | 59.6 | 34.0 | ||
| No | 79 | 37.6 | 15.1 |
DFS = disease-free survival; LNs = lymph nodes; LNR = lymph node ratio; OS = overall survival; pN = metastasis classification of lymph nodes; TNM = tumour-node-metastasis.