Table 1.
Baseline characteristics of Chronic Renal Insufficiency Cohort participants without chronic heart failure by quartile of Initial Kansas City Cardiomyopathy Questionnaire (KCCQ) Score*
| Quartile | I (N=779) | II (N=813) | III (N=766) | IV (N=735) | P Value |
|---|---|---|---|---|---|
| KCCQ Score | ≤74.5 | 74.6–91.7 | 91.8–99.0 | >99 | |
| Age (years) | 60 (10) | 60 (10) | 60 (12) | 58 (11) | 0.001 |
| Female | 55% | 47% | 42% | 35% | <0.001 |
| Race | <0.001 | ||||
| Non-Hispanic White | 32% | 40% | 53% | 56% | |
| Non-Hispanic Black | 51% | 45% | 32% | 29% | |
| Hispanic | 13% | 12% | 10% | 10% | |
| Other | 4% | 3% | 5% | 6% | |
| Diabetes mellitus | 61% | 52% | 39% | 33% | <0.001 |
| Current Smoker | 18% | 13% | 10% | 8% | <0.001 |
| Current Alcohol Use | 42% | 56% | 67% | 70% | <0.001 |
| Cardiovascular Disease** | 41% | 32% | 22% | 16% | <0.001 |
| Body Mass Index (kg/m2) | 35.4 (8.9) | 32.2 (7.4) | 30.2 (6.3) | 29.2 (5.6) | <0.001 |
| Systolic Blood Pressure (mmHg) | 130 (23) | 129 (22) | 125 (20) | 122 (19) | <0.001 |
| Diastolic Blood Pressure (mmHg) | 70 (14) | 70 (14) | 70 (12) | 71 (11) | 0.60 |
| eGFR (mL/min/1.73m2) | 39.2 (16.0) | 40.9 (16.4) | 44.3(16.3) | 50.1 (16.8) | <0.001 |
| 24-hour Urine Protein (g/24hrs.) | 1.2 (2.2) | 1.0 (2.1) | 0.7 (1.5) | 0.6(1.4) | <0.001 |
| Hemoglobin (g/dL) | 12.3 (1.8) | 12.6 (1.8) | 13.1 (1.7) | 13.5 (1.6) | <0.001 |
| Low-density lipoprotein (mg/dL) | 100 (37) | 100 (35) | 100 (34) | 102 (32) | 0.36 |
| High-density lipoprotein (mg/dL) | 47 (15) | 49 (16) | 50 (16) | 50 (16) | <0.001 |
| NT-proBNP (pg/mL)† | 163 (71, 415) | 152 (69, 375) | 119 (58, 273) | 79 (36, 179) | <0.001 |
| Troponin T (pg/mL)† | 13 (6, 24) | 12 (6, 23) | 10 (5, 19) | 8 (4, 16) | <0.001 |
*
Note: Mean (Standard Deviation) reported for continuous variables and percentage for categorical variables. P values are obtained using ANOVA or Kruskal-Wallis tests for continuous variables and Chi-square tests for categorical variables.
**
Cardiovascular disease was defined as a self-reported history of coronary artery disease, myocardial infarction or stroke.
†
Reported as Median (Interquartile Range)
Abbreviations: estimated glomerular filtration rate (eGFR); N-terminal pro b-type natriuretic peptide (NT-proBNP)