Table 4.

Association of time-updated Kansas City Cardiomyopathy Questionnaire (KCCQ) score with incident heart failure in the following year

KCCQ Score	≤74.5		74.6–91.7		91.8–99.0		>99
	OR (95% CI)	p	OR (95% CI)	P	OR (95% CI)	P
Unadjusted	6.77 (3.75 – 12.23)	<0.001	4.54 (2.49 – 8.28)	<0.001	1.68 (0.86 – 3.30)	0.13	ref
Demographic Variables*	6.17 (3.40 – 11.18)	<0.001	3.99 (2.18 – 7.31)	<0.001	1.53 (0.78 – 3.01)	0.22	ref
Clinical Variables**	3.67 (1.90 – 7.10)	<0.001	2.64 (1.37 – 5.07)	0.004	1.35 (0.66 – 2.77)	0.41	ref
Clinical Variables and NTproBNP***	3.69 (1.88 – 7.27)	<0.001	2.67 (1.37 – 5.21)	0.004	1.42 (0.68 – 2.95)	0.35	ref
Clinical Variables, NT-proBNP, LVH, and LV systolic dysfunction****	3.30 (1.66 – 6.52)	0.001	2.18 (1.11 – 4.29)	0.02	1.23 (0.58 – 2.61)	0.58	ref

^*Adjusted for age, sex, ethnicity and site.

^**Adjusted for age, sex, ethnicity, site, diabetes status, history of cardiovascular disease, current smoking, alcohol use, 24-hour urine protein, estimated glomerular filtration rate, systolic blood pressure, body mass index, low-density lipoprotein and high-density lipoprotein levels.

^***Adjusted for above plus NT-proBNP level.

^****Adjusted for above plus LVH and LV systolic dysfunction

Abbreviations: KCCQ: Kansas City Cardiomyopathy Questionnaire; NT-proBNP: N-terminal pro-brain natriuretic peptide; OR: odds ratio; CI: confidence interval; LVH: left ventricular hypertrophy; ref.: reference quartile.