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. Author manuscript; available in PMC: 2015 Jul 23.
Published in final edited form as: J Am Chem Soc. 2015 Jul 8;137(28):8920–8923. doi: 10.1021/jacs.5b05481

Figure 4.

Figure 4

Aptamer turn-on by bifacial polymer nucleic acid. (top left) Spinach aptamer fold, with the fluorogen binding site shown as a dashed line; refolding of U-Spinach by bPoNA (blue) and DFHBI binding, with U tracts shown in red. For clarity, the PEG block is not indicated. (top right) Fluorescence activation of DFHBI by the bPoNA–U-Spinach binary complex, fit to a 1:1 binding model. (bottom) Excitation (blue) and emission (green) spectra for the indicated DFHBI complexes. The excitation and emission intensities follow the same trend.