Figure 6.

Biodistribution of 1 was determined 2, 4, 24, and 48 h postinjection in MCF7 xenograft nude mice (n = 3 per time point). Briefly, organs, blood, and urine were harvested and acid digested for analysis of Gd(III) content by ICP-MS. These data show the most significant accumulation of 1 occurs in the intestines and urine. Accumulation of 1 decreases over time for all organs except the liver. These data suggest clearance of the complex through the renal system. A: All organs, B: all organs except the spleen, intestines, and urine.