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This is an open access article published under an ACS AuthorChoice License, which permits copying and redistribution of the article or any adaptations for non-commercial purposes.
Scheme 1. Synthesis of IR-783 Conjugated Contrast Agents (1 and 2).
Complexes 3 and 4 were designed for orthogonal modification
through isothiocyanate
conjugation to the primary amine. The reaction was performed in the
dark due to the photo-instability of the IR-783 derivative.