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. 2015 Jun 17;137(28):9108–9116. doi: 10.1021/jacs.5b04509

Scheme 1. Synthesis of IR-783 Conjugated Contrast Agents (1 and 2).

Scheme 1

Complexes 3 and 4 were designed for orthogonal modification through isothiocyanate conjugation to the primary amine. The reaction was performed in the dark due to the photo-instability of the IR-783 derivative.