Table 1. Characterization of IR-783 Conjugated Agents (1 and 2) and Precursors (3 and 4) Including log P and Relaxivity at Low and High Fields.
| Log P | relaxivity 1.41 T (60 MHz)a |
relaxivity 7 T (300 MHz)b |
|||
|---|---|---|---|---|---|
| ionic (mM–1 s–1) | molecular (mM–1 s–1) | ionic (mM–1 s–1) | molecular (mM–1 s–1) | ||
| 1 | –1.8 ± 0.2 | 16.7 ± 0.7 | 50.1 ± 2.1 | 4.8 ± 0.4 | 14.4 ± 1.2 |
| 2 | –1.8 ± 0.2 | 17.5 ± 0.4 | 52.5 ± 1.2 | 4.1 ± 0.3 | 12.4 ± 1.2 |
| 3 | –3.0 ± 0.1 | 13.0 ± 0.1 | 39.0 ± 0.3 | 5.1 ± 0.2 | 15.4 ± 0.6 |
| 4 | –1.9 ± 0.1 | 14.9 ± 0.5 | 45.0 ± 1.5 | 5.2 ± 0.3 | 15.9 ± 0.9 |
a
37 °C, pH 7.4 10 mM MOPS buffer.
b
25 °C, pH 7.4 10 mM MOPS buffer.