Table 1.

Summary of Anti-diabetic drugs on cardiovascular risk factors

Medication		Glucose	Weight	Blood Pressure	LDL-C	HDL-C	Triglycerides
Insulin		− − −	+++	−	+/−	++	− −
	Glargine
	Detemir
	Degludec
	Aspart
	Glulisine
	Lispro
	NPH
	Regular
Metformin		− −	+/−	+/−	−	+/−	−
Sulfonylureas		− −	+++	+/−	−	+/−	−
	Glipizide
	Glyburide
(Glibenclamide)
	Glimepiride
	Gliclazide
	Chlorpropamide
	Tolbutamide
Meglitinides		− −	++	+/−	+/−	+/−	+/−
	Nateglinide
	Repaglinide
Thiazolidinediones
	Rosiglitazone	− −	+++	+/−	++	+	+
	Pioglitazone	− −	+++	−	+	++	−
Alpha Glucosidase		− −	+/−	+/−	+/−	+/−	+/−
Inhibitors
	Acarbose
	Miglitol
	Voglibose
GLP-1R agonist		− −	− −	−	−	+/−	−
	Exenatide
	Liraglutide
	Dulaglutide
	Albiglutide
DPP4 inhibitors		−	+/−	+/−	+/−	+/−	−
	Alogliptin
	Sitagliptin
	Saxagliptin
	Linagliptin
	Vildagliptin
SGLT2 inhibitors		−	−	−	+	+	−
	Canagliflozin
	Dapagliflozin
	Empagliflozin

Legend: (−) indicates a reduction, (+) indicates an increase, (+/−) indicates no discernable change in parameter. NPH=Neutral Protamine Hagedorn.