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Interstitial and perivascular fibrosis results from the proliferation of resident fibroblast lineages. Following pressure overload, local signaling from myocytes and non-myocytes, including vascular cells and immune cells, promotes PDGFRα+;Collagen1a1-GFP+ fibroblast proliferation throughout the myocardium. Several markers have specifically been associated with fibroblasts in interstitial and perivascular fibrotic lesions, but are not expressed by all fibroblasts in these areas (+/−).
