Table 1. Fibroblast markers in healthy heart and following pressure overload.
Fibroblasts labelled | Other cell types labelled | |||
---|---|---|---|---|
Healthy adult heart |
Hypertensive disease |
Healthy adult heart |
Hypertensive disease |
|
PDGFRα | All (7,28) | All (7,28) | Epicardium (28) | Epicardium (28) |
Collagen 1a1-GFP | All (7,28) | All (7,28) | Epicardium, large vessels (28) | Epicardium, large vessels (28) |
Tcf21 | All/most (8) | A subset in interstitial and fibrotic lesions | Epicardium (8,42) | Epicardium (42) |
DDR2 | All (18) | All (18) | Epicardium (71) | Epicardium (72) |
Thy1 | Most/all (28, 54) | Most/all (28, 54) | Endothelium, immune cells | Endothelium, immune cells |
αSMA | No expression | A subset in interstitial lesions (28) | Smooth muscle (38), pericytes | Smooth muscle, pericytes, endothelium (9) |
Vimentin | All | All | Multiple cell types including endothelium (22) | Multiple cell types |
Wt1 | - | A subset in interstitial lesions (42) | Epicardium (42, 73) | Epicardium (42) |
Tbx18 | - | A subset in interstitial lesions (42) | Epicardium (42) | Epicardium (42) |
Periostin (secreted) | - | Associated with areas of interstitial and perivascular fibrosis (39, 74) | Valves (75) | - |
FSP1 | Rare (9) | A subset in perivascular lesions (28) | Immune cells (28, 27, 9) | Immune cells (28, 27, 9), endothelial cells (9) |