Skip to main content
. Author manuscript; available in PMC: 2016 Aug 1.
Published in final edited form as: J Mol Med (Berl). 2015 Jul 14;93(8):823–830. doi: 10.1007/s00109-015-1314-y

Table 1. Fibroblast markers in healthy heart and following pressure overload.

The table includes indications regarding the specificity of the markers and references in which they were tested. Markers have been arbitrarily ranked beginning with the overall most robust fibroblast marker, PDGFRα.

Fibroblasts labelled Other cell types labelled
Healthy adult
heart
Hypertensive
disease
Healthy adult
heart
Hypertensive
disease
PDGFRα All (7,28) All (7,28) Epicardium (28) Epicardium (28)
Collagen 1a1-GFP All (7,28) All (7,28) Epicardium, large vessels (28) Epicardium, large vessels (28)
Tcf21 All/most (8) A subset in interstitial and fibrotic lesions Epicardium (8,42) Epicardium (42)
DDR2 All (18) All (18) Epicardium (71) Epicardium (72)
Thy1 Most/all (28, 54) Most/all (28, 54) Endothelium, immune cells Endothelium, immune cells
αSMA No expression A subset in interstitial lesions (28) Smooth muscle (38), pericytes Smooth muscle, pericytes, endothelium (9)
Vimentin All All Multiple cell types including endothelium (22) Multiple cell types
Wt1 - A subset in interstitial lesions (42) Epicardium (42, 73) Epicardium (42)
Tbx18 - A subset in interstitial lesions (42) Epicardium (42) Epicardium (42)
Periostin (secreted) - Associated with areas of interstitial and perivascular fibrosis (39, 74) Valves (75) -
FSP1 Rare (9) A subset in perivascular lesions (28) Immune cells (28, 27, 9) Immune cells (28, 27, 9), endothelial cells (9)