Fig. 8.

Serotonin is reduced in the brain during SIV infection and is partially restored by cART. (a) Serotonin levels in striatum from 79 animals euthanized at various points throughout infection are shown as medians with interquartile ranges. Asterisks (*) indicate whether the nadir during acute infection, or the total values during asymptomatic or chronic infection, were significantly different (P < 0.05) from uninfected controls by Mann-Whitney. Light grey shading represents the acute phase of infection (0–14 dpi), and dark grey shading represents the chronic phase of infection (≥ 35 dpi). (b) Striatal serotonin levels from uninfected animals (Uninf; N = 5), cART-treated, infected animals (cART; N = 5), and untreated, infected animals with terminal disease (SIVT; N = 13) are shown. The statistic shown is a Mann-Whitney U test comparison between Uninf and cART. In both graphs, the dotted line represents the median of uninfected controls.