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. 2014 Nov 30;2:30. doi: 10.1186/s40635-014-0030-1

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© Marbacher et al.; licensee Springer. 2014

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited.

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Cells with DNA damage in hippocampus and basal cortex. Bar graphs demonstrate mean TUNEL-positive cell count of both hemispheres (±SD) subdivided into controls (n = 5) and different degrees of CPP depletion (mild, n = 5; moderate, n = 3; severe, n = 4). Quantification was performed by counting TUNEL-positive cells co-localizing with DAPI (blue) in regions of interest in the hippocampus (A) and basal cortex (B). Histochemistry (C): Co-localization with DAPI (left column) confirmed that TUNEL-positive staining (middle column) was generally in the nucleus (right column). Hollow arrows show DAPI-positive nuclear staining (blue). Filled arrows identify TUNEL-positive cells. Scale bars = 50 μm. *p < 0.05. **p < 0.01.