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. 2015 Feb 12;3:5. doi: 10.1186/s40635-014-0037-7

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© Reddi et al.; licensee Springer. 2015

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited.

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Arachidonic acid-dependent platelet aggregation was reduced in patients with septic shock. Platelet number was not significantly different between septic shock and non-septic shock patients; however, arachidonic acid-induced aggregation was reduced in platelets derived from septic shock patients (red bar) compared with non-septic shock controls (blue bar) (n = 26 to 33 per patient group, p < 0.05). Incubation for 20 min with the ROK inhibitor Y27632 significantly attenuated arachidonic acid-mediated platelet aggregation in whole blood from both septic shock and non-septic shock patients. Arachidonic acid-induced aggregation in the presence of Y27632 was not significantly different from aggregation of unstimulated platelets. (n = 10 to 12 per patient group, * and † p < 0.05).