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. 2015 Feb 12;3:5. doi: 10.1186/s40635-014-0037-7

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© Reddi et al.; licensee Springer. 2015

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited.

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Neither septic shock nor ROK inhibition reduced arachidonic acid-induced LC ₂₀ phosphorylation. Following stimulation with arachidonic acid, Ser19 phosphorylation of LC₂₀ was significantly increased in platelets from both septic shock (red bar) and non-septic shock control (blue bar) patients. Pre-incubation with Y27632 did not significantly attenuate the arachidonic acid-induced increase in Ser19 phosphorylation of LC₂₀. Arachidonic acid-induced Ser19 phosphorylation of LC₂₀ was not different in platelets derived from patients with septic shock compared to those derived from non-septic shock controls. (n = 14 to 15 per patient group, *p < 0.05).