Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2015 Feb 12;3:5. doi: 10.1186/s40635-014-0037-7

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© Reddi et al.; licensee Springer. 2015

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited.

PMC Copyright notice

ROK-dependent myosin phosphatase activity was unchanged in platelets isolated from patients with septic shock. (A) The proportion of the myosin phosphatase regulatory subunit (MYPT) phosphorylated at the ROK substrate site Thr855 did not differ between unstimulated platelets taken from patients with septic shock compared to those taken from non-septic shock controls (n = 22 to 24 in each patient group). (B) Rat mesenteric artery samples were transferred with platelet samples as controls. Treatment with the stable thromboxane A₂ mimetic U46619 increased ROK-dependent Thr855 phosphorylation of MYPT that was attenuated with the ROK antagonist Y-27632; representative data from n = 3.