Figure 5.

Comparison of mitochondrial function between dying and surviving septic mice using prospective stratification of outcome. Mice were subjected to CLP, monitored for BT and stratified into either predicted to die (P-DIE) or predicted to survive (P-SUR). Upon identification, P-DIE and P-SUR mice were always sacrificed in pairs and additionally compared to the healthy animals (CTRL). (A,B) Succinate state II. (C,D) Succinate state III. (E,F) Succinate RC. For all parameters: P-DIE n = 5, P-SUR n = 6 and CTRL n = 5. Solid horizontal bars indicate mean ± SEM.