FIGURE 2.

Bicuculline-sensitive tonic currents are increased in Mecp2^−/Y mice. A, in comparison with WT mice, bicuculline (50 μm) reduced more tonic currents and noise in Mecp2-null mice in the absence of exogenous GABA (baseline). B and C, in the presence of 1 μm or 10 μm GABA, the bicuculline effects on the tonic currents and noise ratio were significantly larger in Mecp2-null neurons than in the WT. D–F, both tonic currents and the noise ratio increased dose-dependently with an increase in GABA concentrations. Such effects were more obvious in Mecp2-null mice. pF, picofarad. *, p < 0.05; **, p < 0.01; ***, p < 0.001; Student's t test.