FIGURE 7.

Structure of rat Ca²⁺/NCS-1 in complex with GRK1 peptide (PDB code 5AFP). A, backbone schematic representation of the NCS-1 in complex with GRK1 peptide, viewed from the binding interface, with α-helices 1–10 indicated. The GRK1 peptide (colored pink) is bound in the hydrophobic crevice. N and C label the N and C termini of the GRK1 peptide. The NCS-1 C-terminal helix 10 is colored green. Ca²⁺ ions are shown as brown spheres. B, detailed view of the hydrophobic interactions between the side chains of GRK1 peptide (pink) and NCS-1. Peptide residues are in italics; residues from the C-terminal region are colored green.