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. 2015 Jun 23;8:640–651. doi: 10.1016/j.nicl.2015.06.005

Table 2.

Summary of DTI correlations with emotion identification in patient groups.

Contrast Cluster no. Voxels x y z p-Value White matter tract/region
Increased axial diffusivity
All patients 1 58,082 3 −4 10 <0.001 Fornix
bvFTD only 1 50,442 2 2 15 <0.001 Fornix
svPPA only 1 27,988 12 −7 3 0.002 Right anterior thalamic radiation
2 2852 −38 1 27 0.02 Left superior frontal lobea
3 36 37 −79 −2 0.05 Right inferior occipital lobea
4 33 40 −68 −4 0.05 Right inferior occipital lobea
Increased radial diffusivity
All patients 1 68,045 3 −10 11 < 0.001 Right anterior thalamic radiation
bvFTD only 1 45,523 2 4 16 <0.001 Fornix
svPPA only 1 48,721 4 −11 9 0.001 Right anterior thalamic radiation
bvFTD > svPPAb 1 443 22 −6 14 0.04 Right anterior thalamic radiation
2 361 46 −10 −22 0.05 Right inferior longitudinal fasciculus
3 82 32 −31 9 0.05 Right inferior fronto-occipital fasciculus
Increased trace diffusivity
All patients 1 63,092 3 −7 10 <0.001 Right anterior thalamic radiation
Decreased fractional anisotropy
bvFTD only 1 1557 −3 29 5 0.02 Genu corpus callosum

Diffusion tensor tractography (DTI) associations of altered white matter diffusivity metrics associated with TASIT emotion identification score are summarised. Cluster numbering indexes statistically independent anatomical associations within each contrast generated using the FSL cluster command. Results are corrected for multiple comparisons at whole brain level using family-wise error correction (p = 0.05) and ordered by statistical significance and size (number of voxels in the cluster). Peak co-ordinates and anatomical associations are based on centre-of-gravity of cluster and are displayed in MNI standard space.

bvFTD, behavioural variant frontotemporal dementia; svPPA, semantic variant primary progressive aphasia.

a

Cluster peak co-ordinates not within JHU ICBM-DTI-81 white-matter atlas (white matter region assigned on visual inspection; other coordinates within white matter tract identified using JHU ICBM-DTI-81 white-matter atlas).

b

Note here and in Fig. 1, this group interaction contrast is based on an inverse correlation with RD.