. 2015 Jun 23;8:640–651. doi: 10.1016/j.nicl.2015.06.005

Table 3.

Summary of DTI correlations with sarcasm identification in patient groups.

Contrast	Cluster no.	Voxels	x	y	z	p-Value	White matter tract/region
Increased axial diffusivity
All patients	1	10,986	33	2	−7	0.005	Right uncinate fasciculus
bvFTD only	1	23,527	11	10	0	0.004	Right anterior thalamic radiation
	2	565	32	−49	38	0.05	Right superior parietal lobe^a
	3	247	14	−67	48	0.05	Right superior parietal lobe^a
	4	111	36	−62	40	0.05	Right superior parietal lobe^a
	5	92	36	−65	31	0.05	Right parieto-occipital lobe^a
	6	76	−56	−29	−10	0.05	Right superior longitudinal fasciculus: temporal part
	7	29	23	−55	53	0.05	Right superior parietal lobe^a
svPPA only	1	389	48	−12	−22	0.04	Right inferior longitudinal fasciculus

Increased radial diffusivity
All patients	1	9125	33	3	−8	0.009	Right uncinate fasciculus
	2	1183	47	−47	2	0.03	Right superior longitudinal fasciculus: posterior part
bvFTD only	1	4686	24	24	−5	0.02	Right uncinate fasciculus
	2	3209	43	−16	−18	0.03	Right inferior longitudinal fasciculus
	3	1127	−16	29	−12	0.04	Left anterior corona radiata
	4	56	45	−54	−8	0.05	Right inferior temporal lobe^a
svPPA only	1	156	53	−11	−22	0.05	Right inferior longitudinal fasciculus

Increased trace diffusivity
All patients	1	9436	33	4	−8	0.007	Right uncinate fasciculus
	2	42	53	−48	6	0.05	Right superior longitudinal fasciculus: posterior part
bvFTD only	1	9436	32	9	−8	0.02	Right uncinate fasciculus
	2	869	−13	30	−12	0.04	Left anterior corona radiata
	3	145	−26	23	−14	0.05	Left uncinate fasciculus
svPPA only	1	154	53	−10	−22	0.05	Right inferior longitudinal fasciculus

Diffusion tensor tractography (DTI) associations of altered white matter diffusivity metrics associated with TASIT total sarcasm identification score are summarised. Cluster numbering indexes statistically independent anatomical associations within each contrast generated using the FSL cluster command. Results are corrected for multiple comparisons at whole brain level using family-wise error correction (p = 0.05) and ordered by statistical significance and size (number of voxels in the cluster). Peak co-ordinates and anatomical associations are based on centre-of-gravity of cluster and are displayed in MNI standard space.

Cluster peak co-ordinates not within JHU ICBM-DTI-81 white-matter atlas (white matter region assigned on visual inspection; other coordinates within white matter tract identified using JHU ICBM-DTI-81 white-matter atlas); bvFTD, behavioural variant frontotemporal dementia; svPPA, semantic variant primary progressive aphasia.