Table 1.
Baseline clinical and imaging variables
| Alteplase (n=1507) | Control (n=1510) | |
|---|---|---|
| Age (years) | ||
| ≤80 | 693 (46%) | 715 (47%) |
| >80 | 814 (54%) | 795 (53%) |
| 18–50 | 58 (4%) | 68 (5%) |
| 51–60 | 98 (7%) | 102 (7%) |
| 61–70 | 187 (12%) | 175 (12%) |
| 71–80 | 350 (23%) | 370 (25%) |
| 81–90 | 703 (47%) | 697 (46%) |
| >90 | 111 (7%) | 98 (6%) |
| NIHSS score* | ||
| 0–5 | 303 (20%) | 304 (20%) |
| 6–10 | 419 (28%) | 428 (28%) |
| 11–15 | 304 (20%) | 295 (20%) |
| 16–20 | 268 (18%) | 271 (18%) |
| >20 | 213 (14%) | 212 (14%) |
| Time to randomisation (h) | ||
| 0 to ≤3 | 431 (29%) | 415 (27%) |
| >3 to ≤4·5 | 575 (38%) | 596 (39%) |
| >4·5 to ≤6 | 501 (33%) | 497 (33%) |
| >6 | 0 | 2 (<1%) |
| Randomising clinician's assessment of acute ischaemic change on prerandomisation imaging | ||
| No change | 890 (59%) | 892 (59%) |
| Possibly change | 359 (24%) | 339 (22%) |
| Definitely change | 258 (17%) | 279 (18%) |
| Expert reader's assessment of acute ischaemic change on prerandomisation imaging | ||
| Scan completely normal | 140 (9%) | 129 (9%) |
| Scan not normal but no sign of any early ischaemic change | 743 (49%) | 781 (52%) |
| Signs of any early ischaemic change | 624 (41%) | 600 (40%) |
| Early ischaemic lesion territory | ||
| Indeterminate | 885 (59%) | 914 (61%) |
| MCA or ACA or border zone | 589 (39%) | 555 (37%) |
| Posterior | 22 (1%) | 36 (2%) |
| Lacunar | 11 (1%) | 5 (<1%) |
| Early ischaemic lesion changes in MCA territory | ||
| None | 925 (61%) | 960 (64%) |
| One-third or less | 357 (24%) | 354 (23%) |
| More than one-third | 225 (15%) | 196 (13%) |
| Early ischaemic lesion size† | ||
| None visible | 885 (59%) | 914 (61%) |
| Small | 110 (7%) | 97 (6%) |
| Medium | 250 (17%) | 250 (17%) |
| Large | 124 (8%) | 137 (9%) |
| Very large | 138 (9%) | 112 (7%) |
| ASPECTS score‡ | ||
| 0–4 | 162 (11%) | 138 (9%) |
| 5–7 | 201 (13%) | 228 (15%) |
| 8–10 | 1144 (76%) | 1144 (76%) |
| Early ischaemic lesion depth of tissue hypoattenuation§ | ||
| None | 892 (59%) | 922 (61%) |
| Mild | 503 (33%) | 492 (33%) |
| Severe | 112 (7%) | 96 (6%) |
| Early ischaemic lesion degree of swelling | ||
| None | 1152 (76%) | 1171 (78%) |
| Mild sulcal effacement | 283 (19%) | 265 (18%) |
| Mild ventricular effacement | 71 (5%) | 73 (5%) |
| Moderate effacement | 1 (<1%) | 0 |
| Severe effacement | 0 | 1 (<1%) |
| Location of hyperattenuated arteries | ||
| None | 1131 (75%) | 1151 (76%) |
| Anterior circulation | 360 (24%) | 342 (23%) |
| Posterior circulation | 16 (1%) | 17 (1%) |
| ICA, or BA, or MCA and ACA | 42 (3%) | 33 (2%) |
| MCA, or ACA, or PCA main | 334 (22%) | 326 (22%) |
| Pre-existing brain changes | ||
| Evidence of atrophy | 1161 (77%) | 1166 (77%) |
| Evidence of leukoaraiosis | 765 (51%) | 782 (52%) |
| Evidence of old infarcts | 685 (45%) | 651 (43%) |
| Evidence of non-stroke lesions | 73 (5%) | 77 (5%) |
Data are number of patients (%). ACA=anterior cerebral artery. ASPECTS=Alberta Stroke Program Early CT Stroke. BA=basilar artery. ICA=internal carotid artery. IST-3=third International Stroke Trial. MCA=middle cerebral artery. NIHSS=National Institutes of Health Stroke Scale. PCA=posterior cerebral artery.
Assesses neurological deficit in stroke.
Refers to IST-3 image reading categorisation of lesion extent (all vascular territories).
Assesses the extent of infarct affecting the MCA territory by subtracting a point for each of ten regions that are involved in the acute ischaemic lesion.
Classed as mild (ie, grey matter attenuation had become the same as normal white matter) or severe (ie, grey and white matter attenuation less than normal white matter).