. 2015 Jul 24;6:155. doi: 10.3389/fphar.2015.00155

Table 1.

Comparison between half-maximum inhibitory concentrations of sumatriptan and its analogs on hNav1.7 sodium channels and of (S)-22b on wild-type and mutated hNav1.4.

Drug	0.1 Hz		10 Hz		0.1 Hz/10 Hz IC₅₀ ratio

	IC₅₀ (μM)	nH	IC₅₀ (μM)	nH
*hNav1.7*
Sumatriptan	2399 ± 56	1.4 ± 0.1	2187 ± 106	1.4 ± 0.1	1,1
20b	127 ± 16	1.2 ± 0.2	54 ± 4	1.1 ± 0.1	2,4
(R)-31b	118 ± 5	1.4 ± 0.1	39 ± 3	1.1 ± 0.1	3,0
(S)-22b	77 ± 10	1.3 ± 0.2	21 ± 2	1.3 ± 0.1	3,7
Mexiletine	338 ± 18	1.4 ± 0.1	114 ± 12	1.0 ± 0.1	3,0
*hNav1.4*
(S)-22b	51 ± 2	1.4 ± 0.1	12 ± 1	1.3 ± 0.1	4,3
*hNav1.4 – F1586C*
(S)-22b	215 ± 5	1.4 ± 0.1	175 ± 9	1.4 ± 0.1	1,2

The values were obtained from the fit of the concentration–response curves illustrated in Figures 2 and 5. The half-maximum inhibitory concentration (IC₅₀) and the slope factor (nH) are given as the fit value ± SE of the fit.