Table 3.
Summary of transcriptome comparison of S. pneumoniae D39 wild-type grown in chemically defined medium (CDM) plus 0.5 mM Co2+ and CDM plus 0 mM Co2+.
| Gene taga | Functionb | Ratioc | P-value |
|---|---|---|---|
| SPD0053 | Amidophosphoribosyltransferase | 2.0 | 2.09E-06 |
| SPD0054 | Phosphoribosylformylglycinamidine cyclo-ligase | 2.0 | 5.29E-08 |
| SPD0055 | Phosphoribosylglycinamide formyltransferase | 2.2 | 1.12E-05 |
| SPD0056 | VanZ protein | 2.4 | 6.93E-05 |
| SPD0057 | Bifunctional purine biosynthesis protein, PurH | 2.5 | 1.28E-07 |
| SPD0187 | Anaerobic ribonucleoside-triphosphate reductase, NrdD | 11.2 | 2.93E-14 |
| SPD0188 | Hypothetical protein | 4.3 | 2.47E-10 |
| SPD0189 | Acetyltransferase, GNAT family protein | 11.0 | 5.44E-10 |
| SPD0190 | Anaerobic ribonucleoside-triphosphate reductase, NrdG | 10.5 | 1.22E-15 |
| SPD0191 | Hypothetical protein | 8.3 | 1.34E-07 |
| SPD0458 | Heat-inducible transcription repressor, HrcA | 2.5 | 1.09E-10 |
| SPD0459 | Heat shock protein, GrpE | 2.1 | 4.82E-09 |
| SPD0558 | Cell wall-associated serine protease, PrtA | 16.6 | 3.89E-14 |
| SPD1461 | Mn2+ ABC transporter, ATP binding protein, PsaB | 8.7 | 2.18E-14 |
| SPD1462 | Manganese ABC transporter, permease protein, PsaC | 8.7 | 2.18E-14 |
| SPD1594 | XRE family Transcriptional regulator | 3.1 | 7.14E-09 |
| SPD1636 | Zn2+-containing alcohol dehydrogenase | 8.4 | 2.05E-14 |
| SPD1637 | MerR family transcriptional regulator | 11.0 | 1.41E-10 |
| SPD1638 | Cation efflux system, CzcD | 20.8 | 0 |
| SPD1965 | Choline binding protein, PcpA | 5.0 | 5.48E-06 |
| SPD2044 | Rod shape-determining protein, MreD | 3.0 | 8.75E-11 |
| SPD2046 | Co2+ ABC transporter, permease protein, CbiQ | 2.0 | 1.22E-09 |
| SPD2049 | CDP-diacylglycerol-glycerol-3-phosphate 3-phosphatidyltransferase PgsA | 2.0 | 1.13E-06 |
| SPD2052 | Hypothetical protein | 2.0 | 6.84E-09 |
aGene numbers refer to D39 locus tags. bD39 annotation/TIGR4 annotation. (Hoskins et al., 2001; Lanie et al., 2007), cRatios (0.5 mM Co2+/0 mM Co2+).