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Most favored docking poses of TCAs onto hSERT. Overlay of TCAs imipramine, desipramine, amitriptyline, clomipramine, carbamazepine, and dihydrocarbamazepine as obtained by superposition of group 3 of docking poses. The ring system of the TCAs, carbamazepine, and dihydrocarbamazepine occupies the external vestibule, and the basic side chain of the TCAs is pointing toward binding site 1. Furthermore, the dibenzazepine ring system is placed near a hydrophobic region (brown) of the protein.
