Figure 3.

Specific mutations and the pathways affected. (A) The number of genes in defined biological pathways with mutations in MF. (B) Genes known to have a role in cancer that were identified as mutated in MF tumor patient (Pt) samples. Genes with an asterisk denote that 2 patients had mutated that gene. (C) Genes known to have a role in cancer that were identified as mutated (+) in 2 or more CTCL cell lines. Underlined genes indicate the mutation is identical between cell lines. Genes with asterisks indicate the mutation is identical in the CCLE. (D) Mutations in genes that function in epigenetic modification and chromatin remodeling were identified in patient samples (red asterisk) and cell lines (blue asterisk). Ac, acetylation; Me, methylation; P, phosphorylation; Ub, ubiquitination. (E) Mutations in genes that function in the IL-2 cytokine pathway were identified in patient samples (red asterisk) and cell lines (blue asterisk).