Fig. 1.

A schematic diagram of gene expression profiling of MDA-MB-231 cells treated with a new HDI (UF010). MDA-MB-231 cells were cultured and then exposed to DMSO (control) or to UF010. Total RNAs were isolated from the treated cells and then processed for hybridization to microarray chips (Affymetrix GeneChip Human Transcriptome Array 2.0). The chips were scanned and data captured. Data were processed (background adjustment, summarization and normalization). The selected statistically significant genes in the experimental groups were analyzed for functional enrichments in certain pathways using Ingenuity Pathway Analysis (IPA) software.